In the emotional, action-packed fifth and final season of Blindspot, Kurt Weller (Sullivan Stapleton), Jane Doe (Jaimie Alexander), Edgar Reade (Rob Brown), Tasha Zapata (Audrey Esparza), Patterson (Ashley Johnson) and Rich DotCom (Ennis Esmer) attempt to carry out a mission with the highest stakes yet. The season begins in the aftermath of the explosion that left Jane watching as a drone targeted the team's safe house. Now on the run and without the extensive resources of the FBI, Jane and the survivors race against the clock to clear their names in the wake of Madeline Burke's (Mary Elizabeth Mastrantonio) rise to power. They must find a way to stop Madeline before she can track them down and take them out once and for all. With their indestructible bond and the help of old friends, can the team pull it off in time?